Archive for CXCR2

Syntrix Publication in Bioorganic & Medicinal Chemistry Letters

Congratulations to Syntrix scientists on their latest publication, which appeared in the journal Bioorganic & Medicinal Chemistry Letters.  Abstract: Blockade of undesired neutrophil migration to sites of inflammation remains an area of substantial pharmaceutical interest.  To effect this blockade, a validated therapeutic target is antagonism of the chemokine receptor CXCR2.  Herein we report the discovery […]

Syntrix Wins U.S. Patent 8,993,541: Aminopyrimidine Carboxamides as CXCR2 Modulators

Congratulations to Syntrix scientists on their latest issued patent at the United States Patent and Trademark Office.  Inventors: Maeda, Dean Y. (Seattle, WA); Zebala, John A. (Sammamish, WA); and Schuler, Aaron D. (Auburn, WA).  Abstract: There are disclosed aminopyrimidinecarboxamide compounds useful as pharmaceutical agents, synthesis processes, and pharmaceutical compositions which include aminopyrimidinecarboxamides compounds. More specifically, […]

Syntrix Wins U.S. Patent 8,981,106: Pyrimidinecarboxamides as CXCR2 Modulators

Congratulations to Syntrix scientists on their latest issued patent at the United States Patent and Trademark Office.  Inventors: Maeda, Dean Y. (Seattle, WA); and Zebala, John A. (Sammamish, WA).  Abstract: There is disclosed pyridine- and pyrimidinecarboxamide compounds useful as pharmaceutical agents, synthesis processes, and pharmaceutical compositions which include pyridine- and pyrimidinecarboxamides compounds. More specifically, there […]

Syntrix Wins U.S. Patent 8,969,365: Thiopyrimidinecarboxamides as CXCR1/2 Modulators

Congratulations to Syntrix scientists on their latest issued patent at the United States Patent and Trademark Office.  Inventors: Maeda, Dean Y. (Seattle, WA); Zebala, John A. (Sammamish, WA); and Schuler, Aaron D. (Auburn, WA).  Abstract: There is disclosed a pyrimidinecarboxamide compound useful as a pharmaceutical agent, synthetic processes, and pharmaceutical compositions which include the pyrimidinecarboxamide […]

Syntrix Publication in Journal of Medicinal Chemistry

Congratulations to Syntrix scientists on their latest publication, which appeared in the ACS Journal of Medicinal Chemistry.  Abstract: The G protein-coupled chemokine receptors CXCR1 and CXCR2 play key roles in inflammatory diseases and carcinogenesis.  In inflammation, they activate and recruit polymorphonuclear cells (PMNs) through binding of the chemokines CXCL1 (CXCR1) and CXCL8 (CXCR1 and CXCR2).  […]

Syntrix Wins U.S. Patent 8,748,623: Pyridinecarboxamides as CXCR2 Modulators

Congratulations to Syntrix scientists on their latest issued patent at the United States Patent and Trademark Office.  Inventors: Maeda, Dean Y. (Seattle, WA); and Zebala, John A. (Sammamish, WA).  Abstract: There is disclosed pyridine- and pyrimidinecarboxamide compounds useful as pharmaceutical agents, synthesis processes, and pharmaceutical compositions which include pyridine- and pyrimidinecarboxamides compounds. More specifically, there […]

Syntrix Reports the Cellular Mechanism of Compounds It Discovered to Treat COPD and Lung Disease in Neonates

Congratulations to Syntrix scientists and their collaborators at Montana State University on their latest publication in The Journal of Pharmacology and Experimental Therapeutics. Signficance: These studies demonstrate that compounds discovered by Syntrix to treat COPD and lung disease in neonates work by inhibiting CXCR1/2, G-protein coupled receptors, via a novel intracellular mechanism. Abstract: The chemokine receptors CXCR1/2 are […]